Increasing the level of a particular DNA recombinase in the brain can significantly increase its cognitive ability. The discovery was led by Professor Hilmar Bading of the Interdisciplinary Neuroscience Center at the University of Heidelberg. Mouse experiments have shown that Dnmt3a2 protein can improve memory. Because this protein affects fearful memory and has the ability to clear this bad memory, the researchers hope that these findings can be used to develop new treatments for traumatic neurosis and other forms of anxiety. The results of this study were published in the journal Molecular Psychiatry.
In an earlier study, scientists found low levels of Dnmt3a2 protein in the brains of older mice. When older animals are injected with the virus that produces this protein, their memory capacity will increase. “Now we have found that increasing Dnmt3a2 levels in the brains of young mice also improves their cognitive ability,†explains Professor Bading. In many different long-term memory tests, including typical Pavlovian conditioning experiments, scientists were able to demonstrate that mice with more Dnmt3a2 performed better.
Dnmt3a2 is an epigenetic regulator that chemically modifies genetic material DNA. The result is a change in the rate of production of a particular protein. Activating gene transcription can transfer genetic information to RNA, and then synthesize new proteins, playing an important role in the consolidation and disappearance of memory. Heidelberg neuroscientists therefore used a similar method to perform "elimination" experiments in patients with anti-therapeutics. This therapy is used to treat traumatic neurosis and is designed to disrupt or even completely eliminate disturbing associations. We found that the brain of mice with higher levels of Dnmt3a2 was able to eliminate the association between a particular area and a more painful stimulus. Said Bading explained.
Heidelberg neuroscientists have discovered a valuable new impetus for the treatment of cognitive impairment. "They can develop new drugs to improve the memory of patients with Alzheimer's disease or with neurodegenerative diseases such as Alzheimer's," Professor Bading said. Researchers have also seen the potential to develop new treatments for anxiety disorders. New drugs that increase the production of enzymes can be combined with anti-therapeutics.
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