Quinolones (Quinolones) are a class of chemically synthesized antibacterial drugs containing 4-quinolone nucleus. It has a wide antibacterial spectrum and strong antibacterial activity, and is widely used in animal husbandry and aquaculture. However, quinolones have potential carcinogenicity and genotoxicity, and they are also prone to drug resistance. Therefore, the problem of residues of quinolones has attracted more and more attention. The US FDA announced in 2005 that it would ban the sale and use of the antibacterial drug enrofloxacin for the treatment of bacterial infections in poultry. The United Nations Food and Agriculture Organization / World Health Organization Joint Committee of Food Additive Experts and the European Union have established maximum residue limits for various quinolones in animal tissues. High-performance liquid chromatography-tandem mass spectrometry is a fast-developing analysis technology in recent years, with high selectivity and sensitivity, strong qualitative ability for antibiotic residues in complex matrices, and high accuracy. Currently the preferred method for ultra-trace residue analysis.
Shimadzu established a method for the determination of 14 quinolone antibiotics in foods of animal origin using Shimadzu ultra-high performance liquid chromatography and triple quadrupole mass spectrometry. After the samples were processed, the ultra-high performance liquid chromatography LC-30A was used to achieve rapid separation within 7 minutes, and the triple quadrupole mass spectrometer LCMS-8040 was used for quantitative analysis. The calibration curve of 14 quinolone antibiotics was drawn internally using an external standard method, with good linearity and a correlation coefficient of over 0.999; precision experiments were performed on standard solutions of different concentrations, and the relative standard deviations of retention time and peak area for 6 consecutive injections Below 0.437% and 4.937%, indicating that the instrument is of good precision.
For more information, please click "Ultra High Performance Liquid Chromatography Triple Quadrupole Mass Spectrometry for Determination of Quinolone Antibiotic Residues in Milk".
About Shimadzu
Shimadzu Enterprise Management (China) Co., Ltd. is a local legal person company established in China in 1999 by Shimadzu Corporation to expand the scale of its business in China.
At present, Shimadzu Enterprise Management (China) Co., Ltd. has 13 branches throughout China, and its business scale is continuously expanding. There are 5 analysis centers in Beijing, Shanghai, Guangzhou, Shenyang and Chengdu; a network of sales agents covering 30 provinces across the country; and more than 60 technical service stations to build a complete system for providing good services to users.
As a global production base, Shimadzu has built a product production and supply system not only for Chinese customers, but also for the world, and strives to build a product production system that meets the requirements of the Chinese market. With the goal of "for the health of mankind and the earth", Shimadzu will always strive to provide users with more advanced products and more satisfactory services.
For more information, please visit Shimadzu's website.
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