Nanoscale optical microscope developed by the University of Manchester

Scientists at the University of Manchester, Professor Li Lin and Wang Zengbo have created a high-resolution optical microscope (Microscope), which breaks the theoretical limit of the optical microscope, can observe the inside of human cells, and can observe live viruses for the first time, and then Identify the cause of the virus. Previously, standard optical microscope operators could only clearly see objects larger than about 0.2 microns in size. Now, researchers can see objects as small as 0.05 microns in normal light.

The team published their results in the journal Nature Communications. The microscope they manufactured broke the record of the smallest object visible to the naked eye and broke the diffraction limit of light. By combining an optical microscope with transparent microspheres-they call it a nanoscale optical microscope, researchers at the University of Manchester have adopted this technique to break the theoretical limitations of optical microscopes.

Today ’s microscopes can observe tiny objects. Electron microscopes can only see the surface of cells, not their structures, and there are no tools to observe living bacteria.
Now, scientists from the School of Mechanical, Aeronautical and Civil Engineering at the University of Manchester believe they can use microscopes to find images of smaller objects in the future. Their method is not limited by any theory on the size of visible objects. The nano-imaging system is based on capturing optical and near-field virtual images (not limited by light diffraction), magnifying them with a microscope, switching through tiny ball lenses, and then magnifying with a standard microscope.
Professor Li initiated and led this research in collaboration with the National University of Singapore and the Data Storage Institute. He believes that their research can prove to be an important development. He said: "This is a world record, a microscope can be so small It can be imaged directly under light that contains various spectrums. "" Not only can we see objects that are 50 nanometers in size, but I believe this is just the beginning, we will also be able to see smaller objects. In theory, we There is no limit to how small objects can be seen. He went on to say: "At present, the common way to observe small objects is to use an electron microscope, even if you can't see the inside of the cell, at least you can see the outside. Optical fluorescence microscopy can indirectly observe the interior of the cell by staining the cell, but this stain cannot penetrate the virus. "
"You can directly see the inside of the cells without staining, and directly see the live virus, which changes the way we study cells, allowing us to observe the virus up close and understand biomedicine for the first time," Professor Li added. Other objects that scientists can observe are electroplated aluminum oxide nanostructures and nanopatterns on Blu-ray CVC discs, which were not visible with previous optical microscopes. (People's Network)

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