â‘ Separation and analysis of the component content of the drug: Since a drug often contains multiple components, the chromatographic method is a method that can be separated and quantified. Such as fat-soluble vitamin tablets, containing chromium vitamins, with C18 column and containing 1% ammonium carbonate
Methanol is the mobile phase. The vitamin B6, D1, A, E can be separated and the content can be determined at one time. Another example is analgesics or antipyretics. This method can also be used to separate and measure the content of each component.
â‘¡ Intermediate control in drug production: When producing antibiotics, we must first understand the existence of the main body and by-products in the fermentation broth. For example: penicillin, tetracycline, cephalosporin, erythromycin, daunorubicin, gentamicin
Fermentation products, such as vegetarian, can be analyzed using mobile phase prepared with C18 column, methanol and buffer, or by ion pair method to analyze the content of the main body and the product. Procaine amide, theophylline and other main content can be determined
Acid glycerin can determine the main body content and its degradation products in order to ensure the heat of the drug.
â‘¢Analyze the residual amount of the drug in the body: This is one of the main contents of recent research on the efficacy of new drugs, such as winter
Lingcao A is a component of plants with anti-cancer effects, but it is highly toxic. It is very important to determine its content in serum. Now you can use the C18 column and methanol water as the mobile phase to determine the serum sample after treatment to obtain
The content. If the content of sulfonamides in serum and urine is not allowed to be too large, C18 column and acidic ethanol can be used as the mobile phase. After determining the content, the most appropriate dosage can be estimated. Another example is tetracycline, barbituric acid,
The content of pain medicine, antipyretic medicine, diabetes medicine, etc. can be determined by using C18 column with methanol and water as mobile phases. Therefore, the application of reversed-phase chromatography is extremely wide.
â‘£Determination of the metabolic products of drugs in various organs, especially to study the existence of metabolites of drugs in serum. Such as measuring keto acid and glutaric acid in serum. The measurement of metabolites in urine is more convenient and does not require complicated pretreatment. Because studying the components in urine can identify the metabolic function of patients, it has important reference value for pathological research or bed diagnosis.
Office Furniture,Office Desk,L Shape Office Desk,Computer L Shape Office Desk
AU-PINY FURNITURE CO., LTD , https://www.aupinyjm.com